The Alpha-Crystallin B antibody (clone 2E8) from MyBioSource.com is a Mouse Monoclonal antibody to Alpha B Crystallin, CRYAB, Crystallin alpha B, HSPB5, and MFM2. This antibody recognizes Human, and Mouse antigen. The Alpha-Crystallin B antibody (clone 2E8) has been validated for the following applications: ELISA, and Western Blot.
Description
alpha-Crystallins are composed of two gene products; alpha-Crystallin A and B, for acidic and basic, respectively. alpha-Crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). They act as molecular chaperones and hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-Crystallin A and B subunits have a 3:1 ratio, respectively. Two additional functions of alpha-crystallins are an autokinase activity and participation in the intracellular architecture. alpha-Crystallin B is expressed widely in many tissues and organs and occurs in many neurological diseases